For the raw cost of the card, the Scarlet Witch is incredibly efficient. The Forced Response upon playing her, however, is potentially devastating.

The best places to use the Scarlet Witch are with heroes who can scout the encounter deck and know what the next card is going to be before playing her. Spider-Woman, Falcon, and Gambit come to mind.

This card is probably still too slow for True-Solo play, but with the release of Organizational Support Quinjet has a new function. While it’s stacking up counters you can also exhaust it to generate extra resources. Quinjet is probably the best pairing for Org Support outside of the S.H.I.E.LD trait.

great Avenger for solo play, taking a standard 3 per player side scheme is fairly easy to get rid off for justice, triggers skilled investigator etc. also has great stats for Justice which lack dmg - 3x 5 dmg activations is just great for 3 cost.

in 3-4 multiplayer not that great when suddenly the same standard side scheme becomes 9-12 thwart... still its playable if one wants to have a side scheme in play, but one way or another gives possibly greater benefit then Sentry.

please remember to count side schemes in Villain deck before you play him - you might find 6 additional threat on main scheme fairly unpleasant :P if you dont find a side scheme.

Absolutely great cheap Avenger for Justice, perfect for leadership-justice Spider Woman to combo with team training/mighty avengers. with 3 in stats and effective 6hp for 3 cost she is monstrous. 2 consequential in attack is less relevant as justice decks are mostly supposed to not-lose the game in early and wait for leadership or aggression to build up and finish anyway.

in normal Justice decks also excellent just for stats.

This card had an errat in RRG 1.7, to specify who should resolve the ability.
It should read:

When Defeated: The defeating player searches the encounter deck and discard pile for a copy of the Misled treachery and shuffles it into their deck.