Symbiotic Space Wizard

Warning: This first pass through this deck can be hard... you have to defend a fair amount as you are not going to have chumps and there are a lot of Upgrades you need to get on the table... Mulligan for Mystical Studies, Warlock's Cape, The Sorcerer Supreme and Symbiote Suit... get those on the table as fast as possible, along with Soul World. You'll need Karmic Staff too, but save Martial Prowess for the second time through.

Once you get that all setup, you have a hand size of 7, and when you Battle Mage, you draw 2 more. You also have seven events you can play that discard 4 or more cards, so you should be flying through your deck. I had 5 pips on Soul World at the end of my last game (Thanos, Expert Campaign, 2-Player with Gamora Aggression), and was still at full (21) health.

Also, with all your upgrades down, you are a 3/3/4 instead of a 1/1/2... makes that free ready with the cape so much more valuable.

Problem Solvers is a great card when their are multiple schemes in play. Exhausting Yourself and any of your Avenger Allies can get you 5 threat off every scheme in play. Bonkers. And of course, use Energy Spear, Inspired, and Laser Blaster on Yondu so he can attack for 5 every turn with No Consequential Damage, Ranged, Overkill, and Piercing.

Have fun.