| Name | Class | C. | Type | Resources | Traits | Pack | Set |
|---|---|---|---|---|---|---|---|
| Silk | Hero | Hero | Web-Warrior. | Silk 1 | Silk | ||
| Smooth as Silk | Hero | 0 | Event | Silk 2 | Silk 1-2 | ||
| Swinging Silk Kick | Hero | 3 | Event | Aerial. Attack. Superpower. | Silk 3 | Silk 3-5 | |
| Wallcrawl | Hero | 1 | Event | Superpower. Thwart. | Silk 4 | Silk 6-7 | |
| Get the Scoop | Hero | 0 | Player Side Scheme | Silk 5 | Silk 8 | ||
| Albert Moon | Hero | 2 | Support | Persona. | Silk 6 | Silk 9 | |
| J. Jonah Jameson | Hero | 3 | Support | Persona. | Silk 7 | Silk 10 | |
| Eidetic Memory | Hero | 1 | Upgrade | Superpower. | Silk 8 | Silk 11 | |
| Organic Webbing | Hero | 2 | Upgrade | Superpower. | Silk 9 | Silk 12 | |
| Outwit | Hero | 2 | Upgrade | Skill. | Silk 10 | Silk 13 | |
| Spider Claws | Hero | 2 | Upgrade | Weapon. | Silk 11 | Silk 14 | |
| Spider Reflexes | Hero | 2 | Upgrade | Superpower. | Silk 12 | Silk 15 | |
| Scarlet Spider: Ben Reilly | Protection | 3 | Ally | Web-Warrior. | Silk 13 | ||
| Spider-Byte: Margo Kess | Protection | 3 | Ally | Web-Warrior. | Silk 14 | ||
| Not Today! | Protection | 1 | Event | Defense. | Silk 15 | ||
| "Stop Hitting Yourself" | Protection | 2 | Event | Attack. | Silk 16 | ||
| Dr. Sinclair | Protection | 2 | Support | Persona. Therapist. | Silk 17 | ||
| Energy Shield | Protection | 0 | Upgrade | Item. Tech. | Silk 18 | ||
| Ready for a Fight | Protection | 1 | Upgrade | Preparation. | Silk 19 | ||
| Stun Gun | Protection | 2 | Upgrade | Tech. Weapon. | Silk 20 | ||
| Madame Web: Julia Carpenter | Basic | 3 | Ally | Web-Warrior. | Silk 21 | ||
| Spider-Man: Peter Parker | Basic | 3 | Ally | Web-Warrior. | Silk 22 | ||
| Across the Spider-Verse | Basic | 2 | Event | Silk 23 | |||
| Investigative Journalism | Basic | 2 | Event | Skill. | Silk 24 | ||
| Energy | Basic | Resource | Silk 25 | ||||
| Genius | Basic | Resource | Silk 26 | ||||
| Strength | Basic | Resource | Silk 27 | ||||
| Silk Sense Overload | Encounter | Obligation | Silk 28 | Silk | |||
| Morlun | Encounter | Minion | Elite. Inheritor. | Silk 29 | Silk Nemesis 1 | ||
| The Great Hunt | Encounter | Side Scheme | Silk 30 | Silk Nemesis 2 | |||
| Hunting the Spider-Bride | Encounter | Treachery | Silk 31 | Silk Nemesis 3-5 | |||
| Spider-Man 2099: Miguel O'Hara | Leadership | 4 | Ally | Aerial. Web-Warrior. | Silk 32 | ||
| Spider-Woman: Jessica Drew | Aggression | 3 | Ally | S.H.I.E.L.D. Web-Warrior. | Silk 33 | ||
| Quick Quip | Justice | 2 | Event | Skill. | Silk 34 | ||
| Atlas | Encounter | Minion | Elite. Thunderbolt. | Silk 35 | Growing Strong 1 | ||
| Grow Invulnerable | Encounter | Side Scheme | Silk 36 | Growing Strong 2 | |||
| Growing Strong | Encounter | Treachery | Silk 37 | Growing Strong 3-4 | |||
| Titanic Proportions | Encounter | Treachery | Silk 38 | Growing Strong 5-6 |