| Name | Class | C. | Type | Resources | Traits | Pack | Set |
|---|---|---|---|---|---|---|---|
| Apocalypse (I) | Encounter | Villain | Mutant. | Age of Apocalypse 101 | Apocalypse 1 | ||
| Apocalypse (III) | Encounter | Villain | Mutant. | Age of Apocalypse 102 | Apocalypse 2 | ||
| Arclight | Encounter | Villain | Brute. Marauder. | NeXt Evolution 70 | Marauders 1 | ||
| Baron Zemo (I) | Encounter | Villain | Thunderbolt. | Agents of S.H.I.E.L.D. 165 | Baron Zemo 1 | ||
| Batroc | Encounter | Villain | Batroc's Brigade. Mercenary. | Agents of S.H.I.E.L.D. 86 | Batroc 1 | ||
| Blockbuster | Encounter | Villain | Brute. Marauder. | NeXt Evolution 71 | Marauders 2 | ||
| Bulldozer (I) | Encounter | Villain | Wrecking Crew. | The Wrecking Crew 46 | Bulldozer 1 | ||
| Chimera | Encounter | Villain | Marauder. Psionic. | NeXt Evolution 72 | Marauders 3 | ||
| Citizen V | Encounter | Villain | Thunderbolt. | Agents of S.H.I.E.L.D. 129 | Thunderbolts 1 | ||
| Collector | Encounter | Villain | Elder. | The Galaxy's Most Wanted 80 | Escape the Museum 1 | ||
| Collector | Encounter | Villain | Elder. | The Galaxy's Most Wanted 81 | Escape the Museum 2 | ||
| Corvus Glaive (I) | Encounter | Villain | Black Order. | The Mad Titan's Shadow 95 | Tower Defense 4 | ||
| Corvus Glaive (II) | Encounter | Villain | Black Order. | The Mad Titan's Shadow 96 | Tower Defense 5 | ||
| Crossbones (I) | Encounter | Villain | Hydra. Mercenary. | The Rise of Red Skull 58 | Crossbones 1 | ||
| Death | Encounter | Villain | Aerial. Horsemen. | Age of Apocalypse 84 | Four Horsemen 4 | ||
| Doctor Octopus (I) | Encounter | Villain | Activation Order 1 | Sinister Motives 94 | The Sinister Six 1 | ||
| Electro (I) | Encounter | Villain | Activation Order 2 | Sinister Motives 95 | The Sinister Six 2 | ||
| Famine | Encounter | Villain | Horsemen. | Age of Apocalypse 82 | Four Horsemen 2 | ||
| Greycrow | Encounter | Villain | Marauder. Mercenary. | NeXt Evolution 73 | Marauders 4 | ||
| Harpoon | Encounter | Villain | Brute. Marauder. | NeXt Evolution 74 | Marauders 5 | ||
| Hela (I) | Encounter | Villain | Asgard. Mystic. | The Mad Titan's Shadow 136 | Hela 1 | ||
| Hela (II) | Encounter | Villain | Asgard. Mystic. | The Mad Titan's Shadow 137 | Hela 2 | ||
| Hobgoblin (I) | Encounter | Villain | Activation Order 3 | Sinister Motives 96 | The Sinister Six 3 | ||
| Kang (The Conqueror) (I) | Encounter | Villain | Temporal. | The Once and Future Kang 1 | Kang 1 | ||
| Klaw (I) | Encounter | Villain | Masters of Evil. | Core Set 113 | Klaw 1 | ||
| Kraven the Hunter (I) | Encounter | Villain | Activation Order 4 | Sinister Motives 97 | The Sinister Six 4 | ||
| M.O.D.O.K. | Encounter | Villain | Aerial. Cyborg. Psionic. | Agents of S.H.I.E.L.D. 103 | M.O.D.O.K 1 | ||
| MaGog | Encounter | Villain | Brute. | Mojo Mania 1 | Magog 1 | ||
| Master Mold (I) | Encounter | Villain | Sentinel. | Mutant Genesis 109 | Master Mold 1 | ||
| Pestilence | Encounter | Villain | Horsemen. | Age of Apocalypse 83 | Four Horsemen 3 | ||
| Piledriver (I) | Encounter | Villain | Wrecking Crew. | The Wrecking Crew 32 | Piledriver 1 | ||
| Proxima Midnight (I) | Encounter | Villain | Black Order. | The Mad Titan's Shadow 92 | Tower Defense 1 | ||
| Proxima Midnight (II) | Encounter | Villain | Black Order. | The Mad Titan's Shadow 93 | Tower Defense 2 | ||
| Red Skull (I) | Encounter | Villain | Hydra. | The Rise of Red Skull 125 | Red Skull 1 | ||
| Riptide | Encounter | Villain | Assassin. Marauder. | NeXt Evolution 75 | Marauders 6 | ||
| Scorpion (I) | Encounter | Villain | Activation Order 5 | Sinister Motives 98 | The Sinister Six 5 | ||
| Unus (I) | Encounter | Villain | Prelate. | Age of Apocalypse 59 | Unus 1 | ||
| Vertigo | Encounter | Villain | Marauder. Mutate. | NeXt Evolution 76 | Marauders 7 | ||
| Vulture (I) | Encounter | Villain | Activation Order 6 | Sinister Motives 99 | The Sinister Six 6 | ||
| War | Encounter | Villain | Horsemen. | Age of Apocalypse 81 | Four Horsemen 1 | ||
| Zola (I) | Encounter | Villain | Android. Hydra. | The Rise of Red Skull 109 | Zola 1 |