Lady Deadpool and Headpool have my vote for the best 'Pool allies because the Amplify icon is generally the easiest to mitigate, at least in solo (stun, confuse, ally block). It does get worse with more players since the villain has more activations per round. You can thwart or attack effectively with Lady Deadpool for as long as she remains in play, and then when you draw a problematic minion, block with her in the next villain phase before the minion even has a chance to activate. A solid card in an aspect with not many options