It's a Bit of a Grey Area

I'm testing out a Basic suite that could easily be adjusted for each Guardian. Venom is the best natural fit, so here we are!

You can check out my Drax deck here: https://marvelcdb.com/deck/view/171564

The focus is on card draw and allies. With Knowhere and The Triskelion, you can run up to 5 allies. With The Power in All of Us and "Welcome Aboard," it's cheap to get allies on the table. On top of that, with the ally limit of 5, it doesn't seem so bad to keep Rocket, Groot, and Drax hanging out on the board until they are needed. Groot can take a decent number of hits, healing along the way. If his health gets too low, let him go and bring him back with Rapid Response. Until there's a good reason to use Rocket and Drax, you can get use from them with Strength in Numbers. Gamora, Ironheart, Hill, and Fury are all there to help get more cards in your hand, and all the Guardian allies help with card draw thanks to Knowhere.

Enhanced Awareness and Physique are there to help guarantee Venom's status effect kickers. Don't be afraid to use them early to boost your economy on follow up turns.

This deck builds fast, especially if you're running with the Milano.

C.I.T.T. and Team Training are pretty optional in this build. I like them to keep allies on the board longer and get some extra use out of them if needed. Make the Call could probably be swapped in to help get Groot or Hill on the table early on.